25 Nov

Change of Directors Interest Notice x 4

Appendix 3Y Change of Director’s Interest Notice + Se e chapter 19 for defined terms. 01/01/20 11 Appendix 3Y Page 1 Rule 3.19A.2 Appendix 3Y Change of Director’s Interest Notice Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public. Introduced 30/ 0 9/01 Amended 01/01/11 Name of entity Rhythm Biosciences Limited ABN 59 619 459 335 We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act. Name of Director Otto Buttula Date of last notice 9 September 202 1 Part 1 - Change of director’s relevant interests in securities In the case of a trust, this includes interests in the trust made available by the responsible entit y of the trust Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part. Direct or indirect interest Indirect Nature of indirect interest (includi ng registered holder) Note: Provide details of the circumstances giving rise to the relevant interest. 1) Newfound Investments Pty Ltd  2) Webinvest Pty Ltd  Date of change 25 November 2021 Appendix 3Y Change of Director’s Int er est Notice + Se e chapter 19 for defined terms. Appendix 3Y Pag e 2 01/01/20 11 No. of securities held prior to change 1) Newfound Investments Pty Ltd  11,001,667 fully paid ordinary shares (ASX: RHY) 134,167 Unlisted options (ASX: RHYAK) e x piring 31 August 2022 134,167 Unlisted options (ASX: RHYAL) expiring 31 July 2024 2) Webinvest Pty Ltd  1 7, 083,334 fully ordinary paid shares (ASX: RHY) 208,334 Unlisted options (ASX: RHYAK) expiring 31 A u gust 2022 208,334 Unl isted options (ASX: RHYAL) expiring 31 July 202 4 Class U nlisted options (ASX: RHYA I ) expiring 31 July 2024 Number acquired 2,000,000 Number disposed Nil Value/Consideration Note: If consideratio n is non - cash, provide details and estimated valuation Refer to N otice of Meeting lodged with ASX on 2 0 October 2021 for further information. Appendix 3Y Change of Director’s Interest Notice + Se e chapter 19 for defined terms. 01/01/20 11 Appendix 3Y Page 3 No. of securities held after chang e 1) Newfound Investments Pty Ltd  11,001,667 fully paid ordinary shares (ASX: RHY) 134,167 Unlisted options (ASX: RHYAK) e x piring 31 August 2022 134,167 Unlisted options (ASX: RHYAL) expiring 31 July 2024 2,0 00 ,000 Un listed options (ASX: RHYAI) expiring 31 July 202 4 2) Webinvest Pty Ltd  1 7 , 083,334 fully ordinary paid shares (ASX: RHY) 208,334 Unlisted options (ASX: RHYAK) expiring 31 A u gust 2022 208,334 Unl isted opti o n s (ASX: RHYAL) expiring 31 July 2024 Nature of change Example: on - market trade, off - market trade, exercise of options, issue of securitie s under dividend reinvestment plan, par t icipation in buy - back 2 ,000,000 u n l isted options issued via shareholder approval received on 2 4 November 2021 - refer to Notice of Meeting lodged with ASX on 20 October 2021 . Part 2 – Change of director’s interests i n contracts Note: In the case of a company, interests which come withi n paragraph (ii) of the d efinition of “notifiabl e interest of a director” sho u ld be disclosed in this part. Detail of contract n/a Nature of interest Name of registered holder ( if issued securities) Date of change No. and class of securities to w h ich interest related p r ior to change Note: Det ails are only required for a c ontract in relation to which the interest has changed Appendix 3Y Change of Director’s Int er est Notice + Se e chapter 19 for defined terms. Appendix 3Y Pag e 4 01/01/20 11 Interest acquired Interest disposed Value/Co ns ideration Note: If consideration is non - cash, provide details and an es t i mated valuation In t erest after change P art 3 – + Closed period Were t he interests in the securities or contracts detailed above traded during a + closed period where prior wri tt en clearance was required? n/a If so, was prior written clearance prov i d ed to allow the trade t o proceed during this p eriod? If prior written cle a rance was provided, on what date was this provided? Appendix 3Y Change of Dire c tor’s Interest Notice + See chapter 1 9 for defined terms. 01/01/20 11 Appendix 3Y Page 1 Rule 3.19A.2 Appendix 3Y Change of Director’s Interest Notice Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public. Introduced 30/ 0 9/01 Amended 01/01/11 Name of entity Rhythm Biosciences Limited ABN 59 619 459 335 We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act. Name of Director Lou Panaccio Date of last notice 9 September 202 1 Part 1 - Change of director’s relevant interests in securities In the case of a trust, this includes interests in the trust made available by the responsible enti t y of the trust Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part. Direct or indirect interest Ind irect Nature of indirect interest (includ i ng registered holder) Note: Provide details of the circumstances giving rise to the relevant interest. Tercus Pty Ltd Date of change 25 November 2021 No. of securities held prior to change Held by Beneficial interest through Tercus Pty Ltd : 8 20 ,0 00 f ully paid ordinary shares (ASX: RHY) 10,000 Unlisted options ( A SX: RHYAK) expiring 31 August 2022 10,000 Unlisted options (ASX: RHYAL) expiring 31 July 2024 Appendix 3Y Change of Director’s Interest Notice + See chapter 19 for defined terms. Appendix 3Y Page 2 01/01/20 1 1 Class U nlisted options (ASX: RHYA I ) expiring 31 July 2024 Number acquired 150,000 Number disp osed Nil Value/Conside r a tion Note: If consideration is non - cash, provide details and estimated valuation Refer to N otice of Meeting lodged with ASX on 20 October 2021 for further information. No. of securities held after change Held by Beneficial intere st t hrough Tercus Pty Ltd : 8 20 ,000 fully paid ordinary shares (ASX: RHY) 10,000 Unlisted options ( A SX: RHYAK) expiring 31 August 2022 1 0,000 Unlisted options (ASX: RHYAL) expiring 31 July 2024 150,000 Unlisted o ptions (ASX: RHYAI) e xpiring 31 July 2024 N ature of change Example: on - market trade, off - market tr ade, exercise of options, issue of securities under dividend reinvestment pla n , participation in buy - back 150,000 unlisted options issued via shareholder approval received on 2 4 November 2021 - ref er t o Not ice of Meeting lodged with ASX on 20 October 2021 for further information. Part 2 – Change of director’s interests in contracts Note: In the case of a company, interests which come within paragraph (ii) o f the definition of “notifia ble interest of a dir ector” should b e disclosed in this part. Detail of contract Nature of i nterest Name of registered holder (if issued securities) Date of change Appendix 3Y Change of Dire c tor’s Interest Notice + See chapter 1 9 for defined terms. 01/01/20 11 Appendix 3Y Page 3 No. and class of securities to which interest relate d prior to change Note: Deta ils are only req uired for a contract in relation to which the interest has changed Interest acquired Interest disposed Value/Consideration Note: If consideration is n o n - cash, provide details and an estimated valuation Interest after change Pa rt 3 – + Closed p eriod Were the inte rests in the securities or contracts detailed above traded during a + closed period where prior written clearance was required? If so, w a s prior written clearance provided to allow the trade t o proceed during this perio d? If prior wr itten clearance was provided, on what date was this provided? Appen dix 3Y Ch ange of Director’s Inter est Notice + See chapter 19 for defined terms. 01/01/2 0 1 1 Appendix 3Y Page 1 Rule 3.19A.2 Appendix 3Y Change of Director’s Interest Notice Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public. Introduced 30/ 0 9/01 Amended 01/01/11 Name of entity Rhythm Biosciences Limited ABN 59 619 459 335 We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act. Name of Director Trevor Lockett Date of last notice 9 September 2021 Part 1 - Change of director’s relevant interests in securities In the case of a trust, this includes interests in the trust made available by the responsible ent ity of the trust Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part. Direct or indirect interest Direct Nature of indirect interest (includ ing registered holder) Note: Provide details of the circumstances giving rise to the relevant interest. Date of change 25 November 2021 No. of securities held prior to change 16 4 ,000 fully paid ordinary shares held by Mrs Linda Jane Lockett & Dr Trevor John Lockett (ASX: RHY) 1,50 0 ,000 unlisted options held by Mrs Linda Jane Lockett & Dr Trevor John Lockett to acquire fully paid ordi nary shares having an exercise price of $0. 2 0 and expiring 14 September 202 3. 2,000 Unlisted options (ASX: RHYAK) expiring 31 August 2022 . 2,000 Unlisted options (ASX: RHYAL) expiring 31 July 2024 . Appendix 3Y Change of Director’s Interest Notice + See chapter 19 for defined terms. Appendix 3Y Page 2 01/01/20 11 Class U nlisted options (ASX: RHYA I ) expiring 31 July 2024 Number acquired 500,000 Number disposed Nil Value/Consideration Note: If consideration is non - cash, provide details a nd estimated valuation Refer to N otice of Meeting lodged with ASX on 20 October 2021 for further information. No. of securities held after change 16 4 ,000 fully paid ordinary shares held by Mrs Linda Jane Lockett & Dr Trevor John Lockett (ASX: RHY) 1,50 0 , 000 unlisted options held by Mrs Linda Jane Lockett & Dr Trevor John Lockett t o acquire fully paid ordi nary shares having an exercise price of $0. 2 0 and expiring 14 September 202 3. 2,000 Unlisted options (ASX: RHYAK) expiring 31 August 2022 2,000 Unlisted options (ASX: RHYAL) expiring 31 July 2024 500 ,000 Un listed options (ASX: RHYAI) expiring 31 July 202 4 Nature of change Example: on - marke t trade, off - market trade , exe rcise of options, issue of securities under dividend reinvestment plan, participation in buy - back 500,000 unlisted options issued via shareholder ap proval received on 2 4 November 2021 - refer to Notice of Meeting lodged with A SX on 20 October 2021 for further info rmation. Part 2 – Change of director’s interests in contracts N ote: In the ca se of a company, interes ts which come within paragraph (ii) of the definition of “no tifiable interest of a director” should be disclosed in this part. Detail o f contract n/a Nature of interest Appen dix 3Y Ch ange of Director’s Inter est Notice + See chapter 19 for defined terms. 01/01/2 0 1 1 Appendix 3Y Page 3 Name of registered holder (if issued securi ties) Date of change No. and clas s of securities to which interest related prior to change No te: Details are only required for a contract in relation to which the intere st has changed Interest acquired Interest disposed Value/Consideration Note : If considera tion is non - cash, provid e details and an estimated valuation Interest after chan ge Part 3 – + Closed period Were the interests in the securities or contr ac ts detailed above traded during a + closed period where prior written clearance w as re quired? n /a If so, was prior wri tten clearance provided to allow the trade to proceed during this period? If prior written clearance was provided, on what date was th is provided? Appendix 3Y Change of Director’s Interest Notice + See ch apter 1 9 for defined terms. 01/01/20 11 Appendix 3Y Page 1 Rule 3.19A.2 Appendix 3Y Change of Director’s Interest Notice Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public. Introduced 30/ 0 9/01 Amended 01/01/11 Name of entity Rhythm Biosciences Limited ABN 59 619 459 335 We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act. Name of Director Eduardo Vom Date of last notice 9 September 2021 Part 1 - Change of director’s relevant interests in securities In the case of a trust, this includes interests in the trust made available by the responsible entit y of the trust Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part. Direct or indirect interest Direct Nature of indirect interest (including registered holder) Note: Provide details of the circumstances giving rise to the relevant interest. Date of change 25 November 2021 No. of securities held prior to change 1) Eduardo Vom 1,164,400 fully paid ordinary shares (ASX: RHY) . 14,200 Unlisted optio ns (ASX: RHYAK) expiring 31 August 2022 . 14,200 Unlisted options (ASX: RHYAL) expiring 31 July 2024 . 2) Natalie Patterson (spouse) - 2, 4 77,084 fully paid ordinary shares (ASX: RHY) . 30,209 Unlisted options (ASX: RHYAK) expiring 31 August 2022 . 30,209 Unlisted options (ASX: RHYAL) expiring 31 July 2024 . Appendix 3Y Change of Director’s Interest Notice + See c hapter 19 for defined term s. Appendix 3Y Page 2 01/01/20 11 Class U nlisted options (ASX: RHYA I ) expiring 31 July 2024 Number acquired 150,000 Number dispos ed Nil Value/ Consideration Note: If consideration is non - cash, provide details and estimated valuation Refer to N otice of Meeting lodged with ASX on 20 October 2021 for further information. No. of securities held after change 1) Eduardo Vom 1,164,400 fully paid or dinary shares (ASX: RHY) 14,200 Unlisted options (ASX: RHYAK) expiring 31 August 2022 14,200 Unlisted option s (ASX: RHYAL) expiring 31 July 2024 150 ,000 Unlisted option s (ASX: RHYAI) expiring 31 July 2024 2) Natalie Patterson (spouse) - 2, 4 77,084 fully paid ordinary shares (ASX: RHY) 30,209 Unlisted options (ASX: R HYAK) expiring 31 August 2022 30 ,209 Unlisted optio ns (ASX: RHYAL) expiring 31 July 2024 Nature of change Example: on - market trade, off - market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy - back 150 , 000 unlisted options issued via shareholder approv al received on 2 4 November 2 021 - refer to Notice of Meeting lodged with ASX on 20 October 2021 for further information. Part 2 – Change of director’s interests in contracts Note: In the case of a company, interests which come within paragraph (ii) of t he definition of “notifi ab le interest of a director” should be disclosed in this part. Detail of contract Nature of interest Appendix 3Y Change of Director’s Interest Notice + See ch apter 1 9 for defined terms. 01/01/20 11 Appendix 3Y Page 3 Name of registered holder (if issued securities) Date of change No. and class of securities t o which interest related pr ior to change Note: Deta il s are only required for a contrac t in relation to which the interest has changed Inte rest acquired Interest disposed Value/Consideration Note: If consideration is non - cash, provide details and an e stimated valuation Int erest after change Par t 3 – + Closed period Were t he inte rests in the securities or contracts detailed above tra ded during a + closed period where prior written clearance was required? If so, was prior written clearance provid e d to allow the trade to pr oceed during this period ? If prior written clearan ce was provided, on what date was this provided?

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