Cautionary Announcement Ascendis Health Limited (Registration number 2008/005856/06) (Incorporated in the Republic of South Africa) Share code: ASC ISIN: ZAE000185005 (“Ascendis Health” or “the Company”) CAUTIONARY ANNOUNCEMENT Shareholders are advised that the Company has commenced the process regarding the potential disposal of its business segment known as “Ascendis Pharma”, which, if successfully concluded, may have a material effect on the price at which the Company’s shares trade. Accordingly, shareholders are advised to exercise caution when dealing in their Ascendis Health shares until a further announcement is made. 13 October 2021 Bryanston Sponsor Questco Corporate Advisory Proprietary Limited 1 Date: 13-10-2021 03:45:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.